Textbook of Receptor Pharmacology 3rd edition

Book Metadata

• Full Title: Textbook of Receptor Pharmacology

• Editors: John C. Foreman, Torben Johansen, and Alasdair J. Gibb

• Authors: Donald H. Jenkinson, Alasdair J. Gibb, Jan Egebjerg, IJsbrand Kramer, Michel Laguerre, Dennis G. Haylett, David A. Brown, Elisabeth Genot, and James W. Black

• Year of Publication: 2011

• Edition: Third Edition

• Total Number of Pages: 314 pages.

Copyright Summary

The Third Edition of this text is published by CRC Press, an imprint of the Taylor & Francis Group. It carries the International Standard Book Number 978-1-4200-5254-1 for the hardback version. All rights are reserved under U.S. Copyright Law, prohibiting unauthorized reproduction or transmission in any form.

Preface Analysis

The authors’ primary intent is to provide a logical, integrated introduction to the study of drug receptors by uniting four major pillars of pharmacology: molecular receptor structure, quantitative functional studies of agonists and antagonists, ligand binding, and signal transduction mechanisms. 

This text aims to fill a clinical and educational gap by consolidating diverse materials into a single, comprehensive reference. Originally developed from courses at University College London, the book is designed for undergraduate and graduate students, as well as research workers in the pharmaceutical industry. 

This edition specifically updates research on receptor-transducer interactions and introduces new ligand-binding techniques.

Chapter List

• Chapter 1: Classical Approaches to the Study of Drug-Receptor Interactions (Donald H. Jenkinson)

• Chapter 2: Structure and Function of 7-TM G-Protein Coupled Receptors (Alasdair J. Gibb)

• Chapter 3: The Structure of Ligand-Gated Ion Channels (Jan Egebjerg)

• Chapter 4: Molecular Structure of Receptor Tyrosine Kinases (IJsbrand Kramer and Michel Laguerre)

• Chapter 5: Direct Measurement of Drug Binding to Receptors (Dennis G. Haylett)

• Chapter 6: Receptors Linked to Ion Channels: Mechanisms of Activation and Block (Alasdair J. Gibb)

• Chapter 7: G-Proteins (David A. Brown)

• Chapter 8: Signal Transduction through Protein Tyrosine Kinases (IJsbrand Kramer and Elisabeth Genot)

• Chapter 9: Receptors as Pharmaceutical Targets (James W. Black)

Clinical Value Prop: Why Read This?

For the practicing physician or clinical researcher, this textbook offers a rigorous quantitative foundation for understanding drug action at the molecular level. It moves beyond qualitative descriptions to explain how receptor structure determines signal transduction and therapeutic outcomes. 

With over 40% of prescription medicines currently targeting G-protein coupled receptors (GPCRs), the insights provided into receptor dimerization, desensitization, and pharmaceutical targeting are fundamental for those involved in drug development, clinical trials, or precision medicine.

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